The rise of tamoxifen : Temporal and geographical trends of tamoxifen use in Ontario
Identifieur interne : 002570 ( Main/Exploration ); précédent : 002569; suivant : 002571The rise of tamoxifen : Temporal and geographical trends of tamoxifen use in Ontario
Auteurs : V. A. Palda [Canada] ; V. Goel [Canada] ; C. A. Sawka [Canada]Source :
- Breast cancer research and treatment [ 0167-6806 ] ; 1997.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme, Santé publique, Consommation.
English descriptors
- KwdEn :
Abstract
Purpose: To describe the change in use of tamoxifen over time and across countries in Ontario. Methods: Data from the Ontario Drug Benefit (ODB) plan, Census Canada, and the Ontario Cancer Registry (OCR) were combined and analysed to determine rates of tamoxifen use for females over 65 for each county and the province overall, by year. Rates were analyzed by repeated measures ANOVA to determine significance of changes over time. Consistency of tamoxifen use across counties was determined by the Spearman rank correlation coefficient, and overall variation between counties was described using three statistical techniques: Chi-square analysis, the extremal quotient (EQ), and the systematic component of variation (SCV). Results: The number of one-month tamoxifen prescriptions per incident case of breast cancer rose significantly from 13.51 in 1985 to 20.54 in 1990 (p < 0.001) and to 34.06 in 1992 (p = 0.001). Viewed differently, the number of women over 65 receiving tamoxifen prescriptions per incident case of breast cancer changed from 1.91 in 1985 to 3.14 in 1990 to 4.54 in 1992. Statistically significant variation in the rate of tamoxifen prescribing was demonstrated between Ontario counties in all three years by Chi Squared analysis (p < 0.0001). Both the EQ and the SCV declined from 1985 to 1990, suggesting more uniform prescribing across the province. Little change in overall variation was seen between 1990 and 1992. All counties over time tended to prescribe generic preparations more often and shifted from 10 mg to 20 mg formulations. Conclusions: The significant increase in the rate of tamoxifen use and trend towards more uniform prescribing across Ontario between 1985 and 1990 coincided with the publication of two important documents outlining the benefits of tamoxifen in early breast cancer. Despite this trend, variation in tamoxifen use between counties remains. There has been little change in uniformity of prescribing since 1990.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000941
- to stream PascalFrancis, to step Curation: 000A58
- to stream PascalFrancis, to step Checkpoint: 000872
- to stream Main, to step Merge: 002703
- to stream Main, to step Curation: 002570
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The rise of tamoxifen : Temporal and geographical trends of tamoxifen use in Ontario</title><author><name sortKey="Palda, V A" sort="Palda, V A" uniqKey="Palda V" first="V. A." last="Palda">V. A. Palda</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Program in Clinical Epidemiology and Health Care Research (Sunnybrook Unit), University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Goel, V" sort="Goel, V" uniqKey="Goel V" first="V." last="Goel">V. Goel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Program in Clinical Epidemiology and Health Care Research (Sunnybrook Unit), University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Sawka, C A" sort="Sawka, C A" uniqKey="Sawka C" first="C. A." last="Sawka">C. A. Sawka</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Program in Clinical Epidemiology and Health Care Research (Sunnybrook Unit), University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Toronto-Sunnybrook Regional Cancer Centre</s1><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto-Sunnybrook Regional Cancer Centre</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">97-0226825</idno><date when="1997">1997</date><idno type="stanalyst">PASCAL 97-0226825 INIST</idno><idno type="RBID">Pascal:97-0226825</idno><idno type="wicri:Area/PascalFrancis/Corpus">000941</idno><idno type="wicri:Area/PascalFrancis/Curation">000A58</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000872</idno><idno type="wicri:doubleKey">0167-6806:1997:Palda V:the:rise:of</idno><idno type="wicri:Area/Main/Merge">002703</idno><idno type="wicri:Area/Main/Curation">002570</idno><idno type="wicri:Area/Main/Exploration">002570</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The rise of tamoxifen : Temporal and geographical trends of tamoxifen use in Ontario</title><author><name sortKey="Palda, V A" sort="Palda, V A" uniqKey="Palda V" first="V. A." last="Palda">V. A. Palda</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Program in Clinical Epidemiology and Health Care Research (Sunnybrook Unit), University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Goel, V" sort="Goel, V" uniqKey="Goel V" first="V." last="Goel">V. Goel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Program in Clinical Epidemiology and Health Care Research (Sunnybrook Unit), University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Sawka, C A" sort="Sawka, C A" uniqKey="Sawka C" first="C. A." last="Sawka">C. A. Sawka</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Program in Clinical Epidemiology and Health Care Research (Sunnybrook Unit), University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Toronto-Sunnybrook Regional Cancer Centre</s1><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto-Sunnybrook Regional Cancer Centre</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Breast cancer research and treatment</title><title level="j" type="abbreviated">Breast cancer res. treat.</title><idno type="ISSN">0167-6806</idno><imprint><date when="1997">1997</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Breast cancer research and treatment</title><title level="j" type="abbreviated">Breast cancer res. treat.</title><idno type="ISSN">0167-6806</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiestrogen</term><term>Chemotherapy</term><term>Consumption</term><term>Epidemiology</term><term>Female</term><term>Geographical variation</term><term>Human</term><term>Malignant tumor</term><term>Mammary gland</term><term>Non steroid compound</term><term>Ontario</term><term>Oral administration</term><term>Public health</term><term>Statistical analysis</term><term>Tamoxifene</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tamoxifène</term><term>Voie orale</term><term>Epidémiologie</term><term>Chimiothérapie</term><term>Tumeur maligne</term><term>Glande mammaire</term><term>Homme</term><term>Femelle</term><term>Traitement</term><term>Ontario</term><term>Analyse statistique</term><term>Santé publique</term><term>Composé non stéroïde</term><term>Antioestrogène</term><term>Consommation</term><term>Variation géographique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Santé publique</term><term>Consommation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: To describe the change in use of tamoxifen over time and across countries in Ontario. Methods: Data from the Ontario Drug Benefit (ODB) plan, Census Canada, and the Ontario Cancer Registry (OCR) were combined and analysed to determine rates of tamoxifen use for females over 65 for each county and the province overall, by year. Rates were analyzed by repeated measures ANOVA to determine significance of changes over time. Consistency of tamoxifen use across counties was determined by the Spearman rank correlation coefficient, and overall variation between counties was described using three statistical techniques: Chi-square analysis, the extremal quotient (EQ), and the systematic component of variation (SCV). Results: The number of one-month tamoxifen prescriptions per incident case of breast cancer rose significantly from 13.51 in 1985 to 20.54 in 1990 (p < 0.001) and to 34.06 in 1992 (p = 0.001). Viewed differently, the number of women over 65 receiving tamoxifen prescriptions per incident case of breast cancer changed from 1.91 in 1985 to 3.14 in 1990 to 4.54 in 1992. Statistically significant variation in the rate of tamoxifen prescribing was demonstrated between Ontario counties in all three years by Chi Squared analysis (p < 0.0001). Both the EQ and the SCV declined from 1985 to 1990, suggesting more uniform prescribing across the province. Little change in overall variation was seen between 1990 and 1992. All counties over time tended to prescribe generic preparations more often and shifted from 10 mg to 20 mg formulations. Conclusions: The significant increase in the rate of tamoxifen use and trend towards more uniform prescribing across Ontario between 1985 and 1990 coincided with the publication of two important documents outlining the benefits of tamoxifen in early breast cancer. Despite this trend, variation in tamoxifen use between counties remains. There has been little change in uniformity of prescribing since 1990.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Palda, V A" sort="Palda, V A" uniqKey="Palda V" first="V. A." last="Palda">V. A. Palda</name></region><name sortKey="Goel, V" sort="Goel, V" uniqKey="Goel V" first="V." last="Goel">V. Goel</name><name sortKey="Sawka, C A" sort="Sawka, C A" uniqKey="Sawka C" first="C. A." last="Sawka">C. A. Sawka</name><name sortKey="Sawka, C A" sort="Sawka, C A" uniqKey="Sawka C" first="C. A." last="Sawka">C. A. Sawka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/OcrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002570 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002570 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= OcrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:97-0226825
|texte= The rise of tamoxifen : Temporal and geographical trends of tamoxifen use in Ontario
}}
| This area was generated with Dilib version V0.6.32. |  |